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| Unique genetic markers called oligonucleotides can provide swift identification of a known organism or rule out an organism from known genomes. This software technology provides a way to generate thousands of such markers much more rapidly than PCR, as well as providing a searchable database of chromosomal sequences for over 100 pathogens and near-neighbor organisms, unique plasmid sequences, and markers for virulence and antibiotic-resistance genes in a platform-independent format. Using the technology, the existing database can be extended to any DNA-based organisms. Markers allow rapid identification at the genus, species, and even strain level. The technology has manifold applications in research, clinical uses, and in bio-threat assessment. Markers already exist for diseases such as Ebola, dengue fever, Norwalk virus, Yersinia Pestis, and over 100 others. With as few as 20 DNA fragments, the system can achieve a 99% confidence of no false negatives against a library of samples, and a 1% false positive. PCR techniques offer 10% false positives.Embodiments systems indentify genomic sequences informative biological characteristics sample along gathering information sets organisms present Specific embodiments relate microbial |
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