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| Adult nerves of the mammalian central nervous system (CNS) show poor regenerative ability after axonal injury. The failure to regenerate has been attributed to the inhospitable nature of the nerve's environmental milieu, including the formation of mature oligodendrocytes which inhibit axonal growth. Interleukin-2 (IL-2), a lymphokine synthesized and secreted by T cells after activation, is upregulated in the brain following brain injury. This invention described a human dimeric IL-2 produced by enzymatic activity of nerve-derived transglutaminase which is selectively toxic to oligodendrocytes. No safe effective means for causing regenerative growth of CNS axons in mammals has yet been developed. A pharmaceutical which can be injected at the site of desired regeneration may help alleviate post-traumatic paraplegia or quadriplegia, blindness, deafness, surgically associated axotomy, etc.novel compound dimeric interleukin-2 (IL-2) derived incubation nerve-derived transglutaminase pharmaceutical mean induce facilitate regeneration |
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