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| The present invention relates to novel derivatives of avidin-type molecules, particularly to antigen-antibody complexes of avidin-type molecules, and to compositions comprising them for targeted diagnostic and therapeutic treatment of the liver and the reticuloendothelial system. Drug delivery, using targeting systems wherein a drug or radioactive isotope are coupled to a specific targeting vehicle, has been studied for both therapeutic and diagnostic potentials. Avidins are enzyme resistant carriers that can serve to provide selective and prolonged organ accumulation to ensure prolonged maintenance of these carriers in the target organ. While native avidins are mainly localized to the kidney, chemical modifications can change the in vivo disposition profile of these macromolecules. This invention provides such modifications that shift the accumulation of avidin-type molecules from the kidney to the liver or to the reticuloendothelial system, where they remain for several days. Thus, these macromolecules may act as homing devices to a specific organ and can be used as more specific and efficient drug delivery systems.present relates novel derivatives avidin-type molecules antigen-antibody complexes compositions targeted diagnostic therapeutic treatment liver reticuloendothelial |
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