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| The present invention relates to inhibition of growth factor tyrosine kinase receptor activity, particularly inhibition of angiogenesis and related disorders, tumor progression and growth factor related skeletal disorders, by porphyrin and corrole compounds, and to certain novel porphyrin compounds. Growth factors play a pivotal role in the multistep pathway of cell differentiation and migration, tumor and metastasis progression, and angiogenesis. Porphyrins interact with neoplastic tumors and demonstrate high affinity to tumorigenic cells in vitro and solid tumors in vivo. Corroles are slightly contracted porphyrins. The current invention shows that certain porphyrin and corrole compounds can inhibit growth factor receptor tyrosine kinase activity. These compounds have the potential to be used to inhibit cell proliferation and migration in the treatment of primary tumors and metastasis that rely on growth factor signaling. They may also be useful in treating coronary angioplasty, conditions of pathological angiogenesis and bone and cartilage related disorders.present relates inhibition growth factor tyrosine kinase receptor activity angiogenesis related disorders tumor progression skeletal porphyrin corrole compounds certain novel |
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