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| The present invention relates to organ transplantation in humans in general, and more specifically to prevention of graft-versus-host-disease (GVDH), particularly in bone marrow transplantation. Pharmaceutical compositions comprising as active ingredient a synthetic random copolymer with specific properties regarding molecular weight and amino acid composition (GLAT polymer), can be used in a method for prevention and treatment of GVDH in patients in the course of bone marrow and organ transplantation. These peptides bind to the histo-compatibility molecules and compete with binding of antigens to which they are closely related to. If these antigens are related to the development of GVDH, this process may prevent the activation of the immune system against this antigen, thereby preventing the onset of GVDH.present molecular weight synthetic random copolymer glutamic acid (Glu) lysine (Lys) alanine (Ala) tyrosine (Tyr) residues (GLAT) treat prevent graft-versus-host disease (GVH) following bone-marrow transplants organ |
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