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Hollow Radiopaque Bioactive Microspheres As Injectable Biomaterials Based On MMA EIMA Co-polymers Which Are Ideal For Drug Carrying Embolization Procedures
The number of applications of synthetic biomaterials continues to expand. However, the imaging of injected biomaterials is important to control the treatment procedure in real time, to avoid complications and to assess therapeutic success. Embolization is the obstruction of the blood flow in a vessel that can be an effective treatment for tumors in Hepatocellular carcinoma or for uterine fibroids. By combining this embolization therapy with a localized drug delivery the treatment can even be more effective. The material that is currently used is not radiopaque and can therefore cause difficulties for the interventional radiologist during placement of the embolic in the right place. Therefore the hollow, drug carrying microspheres were made radiopaque. Our client has developed a polymer from a copolymer of MMA (methylmethacrylate) and 4-IEMA - an iodine based molecule. This results in a polymer that highly absorbs x-rays (radiopaque). The hollow spheres, can carry drugs and are radiopaque making them ideal for certain medical applications such as new traceable bulking agents.challenge visualize microspheres embolization procedures interventional radiologist estimate devascularization angiography know precise site blockade injected actual location traditionally patients pathological examination

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