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| This technology provides a straightforward biological process for the manufacture of resveratrol starting from glucose. Resveratrol is reported to have many beneficial health effects. Resveratrol is a potent antioxidant, decreasing low density lipid (LDL) oxidation, a factor associated with the development of atherosclerosis (Manna et al., J. lmmunol., 164:6509-6519 (2000)). It is also reported to lower serum cholesterol levels and the incidents of heart disease. This effect has been attributed to a phenomenon known as the "French Paradox". French citizens that regularly consume red wine tend to have lower incidents of heart disease and serum cholesterol levels even though this same group tends to consume foods high in both fat and cholesterol. There is also evidence that resveratrol may have other cardiovascular protective effects including modulation of vascular cell function, suppression of platelet aggregation, and reduction of myocardial damage during ischemia-reperfusion (Bradamante et al., Cardiovasc. Drug. Rev., 22(3):169-188 (2004)). Resveratrol is reported to have anti-inflammatory effects associated with the inhibition of the cyclooxygenase-1 (Cox-1), an enzyme associated with the conversion of chidonic acid to pro-inflammatory mediators. It may also aid in the inhibition of carcinogenesis (Schultz, J., J Natl Cancer Inst., 96(20):1497-1498 (2004); Scifo et al., Oncol Res., 14(9):415-426 (2004); and Kundu, J. and Surh, Y., Mutat Res., 555(1-2):65-80 (2004)).production resveratrol recombinant oleaginous microorganism |
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