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| This process produces optically active phosphine oxide at 1/10 the cost of the conventional process. Optically active phosphorus compounds such as the Lynn compound are indispensible to asymmetric synthesis, but producing such compounds currently is complicated and expensive. AIST has developed this process, which extensively reacts chiral phosphinate, organic lithium, or the Grignard reagent. It efficiently produces optically active phosphine oxide. Consequently, the indispensible optically active phosphine oxide can be manufactured at 1/10 or less the cost of the current conventional process. Optically active phosphine oxide is used in many reactions and compounds, and is valuable in the production of medicines and similar supplies.optically active phosphorous compound R- S-type absolute simple manner efficiency avoiding racemization phosphorus represented general formula (III) reacting (I) metal (II) water R1 represents hydrogen atom analkyl group cycloalkyl aralkyl aryl R2 alkenyl alkoxy aryloxy heterocyclic ring residue silyl-containing R3M lithium magnesium halide MgX (X=Cl Br |
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