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| - The National Institute of AIST, Japan have clarified that the function of PER1 gene, which is a homolog of human PERLD1 (a potential oncogene), is involved in the maturation of the lipid moiety of the glycosylphosphatidylinositol (GPI) anchors.<BR> - When PER1 becomes abnormal, GPI-anchored proteins cannot exist in their specified primary sites of the cell surface.<BR> - This phenomenon will be related to the mechanism of carcinogenesis and will suggest a new pathway for early detection and curative technologies for cancer.<BR>shown Figure known lipid remodeling final components GPI mechanism physiological role unclear AIST tried genes related pathway budding yeast cells PER1 investigation clarified PER1is removal fatty acyl chain replacing two chains first clarification the |
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