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We would like to come up with a method that can non-invasively assess the microarchitecture of deep-seated central skeletal bones, and provide data that can be correlated or translated to bone strength. With this knowledge, we can monitor changes in bone microarchitecture for sites such as the hip and spine and identify a person at high risk for fracture in order to intervene with a course of therapy. Osteoporosis surveillance and treatment OVERVIEWWe seeking clinically-useful enough sensitivity assess microstructure spongy bone found marrow cavities whole bones skeletal sites surrounded layers soft tissues spine hip Soft interferes conventional imaging accessible area -- wrist ankle limbs-- proxy less regions accurate non-radioactive strongly preferred BACKGROUNDThe structural tiny (the trabecular microarchitecture) cavity difficult image Trying complicated noise surrounding Studies reported profound compartments certain stresses conditionsUnlike commonly recognized diseases osteoporosis targeted specific skeleton suggests factors mineral loss seeing circulate body local affected particular words measurements conducted periphery reflect predict located centrally emerged assessment structures high-resolution peripheral (wrist ankle) closer surface signal detected better (greater noise) similar pronounced total mass occurring disruption suspected CONSTRAINTSo MRI (Magnetic Resonance Imaging) SOLUTION AREASMRI spectroscopyMicro-imaging negative-refractive index lensesNoise-reduction technologyUltrasound sonic |
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