{"id":15267,"date":"2025-06-24T10:34:32","date_gmt":"2025-06-24T14:34:32","guid":{"rendered":"https:\/\/www.yet2.com\/active-projects\/csl%e6%b1%82%e3%82%80%ef%bc%9a%e9%81%ba%e4%bc%9d%e5%ad%90%e5%8c%bb%e7%99%82%e3%81%b8%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%a2%e3%83%97%e3%83%ad%e3%83%bc%e3%83%81\/"},"modified":"2025-06-24T10:34:32","modified_gmt":"2025-06-24T14:34:32","slug":"csl-seeking-novel-approaches-for-genetic-medicine","status":"publish","type":"project","link":"https:\/\/www.yet2.com\/jp\/active-projects\/csl-seeking-novel-approaches-for-genetic-medicine\/","title":{"rendered":"CSL\u6c42\u3080\uff1a\u907a\u4f1d\u5b50\u533b\u7642\u3078\u306e\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1"},"content":{"rendered":"

\"\"<\/p>\n

CSL\u306e\u30aa\u30fc\u30d7\u30f3\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u6295\u7a3f\u30dd\u30fc\u30bf\u30eb\u3078\u3088\u3046\u3053\u305d<\/strong><\/p>\n

CSL\u306f\u3001\u751f\u547d\u3092\u8105\u304b\u3059\u75c5\u72b6\u3092\u6301\u3064\u4eba\u3005\u304c\u5145\u5b9f\u3057\u305f\u751f\u6d3b\u3092\u9001\u308c\u308b\u3088\u3046\u3001\u9769\u65b0\u7684\u306a\u30d0\u30a4\u30aa\u6cbb\u7642\u85ac\u3092\u958b\u767a\u30fb\u63d0\u4f9b\u3059\u308b\u4e16\u754c\u6709\u6570\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002CSL\u306eDNA\u306b\u306f\u30011\u4e16\u7d00\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u9769\u65b0\u304c\u53d7\u3051\u7d99\u304c\u308c\u3066\u3044\u307e\u3059\u3002CSL\u306f\u30016\u3064\u306e\u5c02\u9580\u6cbb\u7642\u9818\u57df\u306b\u304a\u3044\u3066\u3001\u7814\u7a76\u30fb\u81e8\u5e8a\u958b\u767a\u304b\u3089\u88fd\u9020\u30fb\u5546\u696d\u5316\u307e\u3067\u3001\u3042\u3089\u3086\u308b\u5f37\u307f\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002CSL\u306e\u5f37\u307f\u306f\u3001\u60a3\u8005\u3055\u3093\u306e\u305f\u3081\u306b\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3092\u6b63\u78ba\u306b\u7279\u5b9a\u3057\u3001\u958b\u767a\u306b\u6210\u529f\u3057\u3001\u78ba\u5b9f\u306b\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n

CSL\u3067\u306f\u3001\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3092\u8fc5\u901f\u306b\u9032\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u3053\u306e\u5206\u91ce\u3067\u6700\u3082\u512a\u79c0\u306a\u982d\u8133\u3092\u6301\u3064\u4eba\u3005\u3068\u63d0\u643a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002CSL\u306f\u3001\u30d1\u30fc\u30c8\u30ca\u30fc\u30b7\u30c3\u30d7\u306b\u3088\u3063\u3066\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u304c\u52a0\u901f\u3055\u308c\u3001\u6551\u547d\u30fb\u4fdd\u8b77\u306b\u5f79\u7acb\u3064\u65b0\u85ac\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u304a\u308a\u3001\u4e16\u754c\u4e2d\u306e\u60a3\u8005\u3055\u3093\u306e\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30cb\u30fc\u30ba\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306b\u3001\u72ec\u81ea\u306e\u6280\u8853\u3001\u8cc7\u7523\u3001\u8a2d\u5099\u3092\u6301\u3064\u5916\u90e8\u7d44\u7e54\u3068\u5354\u529b\u30fb\u9023\u643a\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n

CSL\u306e\u95a2\u5fc3\u5206\u91ce\u306b\u95a2\u9023\u3059\u308b\u65b0\u88fd\u54c1\u3001\u65b0\u6280\u8853\u3001\u307e\u305f\u306f\u65b0\u305f\u306a\u9032\u6b69\u306b\u95a2\u3059\u308b\u30a2\u30a4\u30c7\u30a2\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u3001\u4ee5\u4e0b\u306e\u30d5\u30a9\u30fc\u30e0\u304b\u3089\u304a\u6c17\u8efd\u306b\u304a\u5bc4\u305b\u304f\u3060\u3055\u3044\u3002 \u6295\u7a3f\u30d5\u30a9\u30fc\u30e0<\/em><\/a>.\u3059\u3079\u3066\u306e\u6295\u7a3f\u306fyet2\u306b\u3088\u3063\u3066<\/em>\u5be9\u67fb\u3055\u308c\u3001\u63a1\u7528\u3055\u308c\u305f\u5834\u5408\u306fCSL\u3068\u5171\u6709\u3055\u308c\u307e\u3059\u3002\u6700\u521d\u306e\u6295\u7a3f\u306b\u306f\u3001\u6a5f\u5bc6\u60c5\u5831\u3092\u542b\u3081\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002 <\/p>\n

\u30a2\u30fc\u30ea\u30fc\u30b9\u30c6\u30fc\u30b8\u306b\u304a\u3051\u308b\u63d0\u643a\u306e\u6838\u3068\u306a\u308b\u5229\u76ca<\/h5>\n

\u907a\u4f1d\u5b50\u7de8\u96c6<\/a><\/p>\n

    \n
  1. \u751f\u4f53\u5185\u306b\u304a\u3051\u308b<\/em>\u5927\u898f\u6a21\u633f\u5165\u7de8\u96c6\u52b9\u7387\u306e\u5411\u4e0a<\/li>\n
  2. \u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u5b89\u5168\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u6280\u8853\uff0f\u30a2\u30c3\u30bb\u30a4<\/li>\n
  3. \u5927\u578b\u6838\u9178\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306e\u9001\u9054<\/li>\n<\/ol>\n

    \u907a\u4f1d\u5b50\u767a\u73fe<\/a><\/p>\n

      \n
    1. \u95a2\u5fc3\u907a\u4f1d\u5b50\uff08GOI\uff09\u306e\u7d44\u7e54\/\u7d30\u80de\u7279\u7570\u7684\u307e\u305f\u306f\u5236\u5fa1\u53ef\u80fd\u306a\u767a\u73fe<\/li>\n
    2. \u514d\u75ab\u7cfb\u7d30\u80de\u306e\u5236\u5fa1\u3092\u5f37\u5316\u3059\u308b\u907a\u4f1d\u5b50\u8981\u7d20<\/li>\n
    3. GOI\u3092\u6301\u7d9a\u7684\u306b\u767a\u73fe\u3055\u305b\u308bRNA\/DNA\u30d9\u30af\u30bf\u30fc<\/li>\n
    4. RNA\u4fee\u98fe\uff08\u5869\u57fa\u4fee\u98fe\u3001Cap\u3001\u30dd\u30eaA\u30c6\u30fc\u30eb\uff09<\/li>\n<\/ol>\n

      \u751f\u4f53\u5185<\/em>\u907a\u4f1d\u5b50\u5c0e\u5165<\/a><\/p>\n

        \n
      1. \u30ca\u30ce\u7c92\u5b50\uff08LNP\u307e\u305f\u306f\u305d\u306e\u4ed6\uff09\u306e\u9054\u6210\uff1a\n