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Novel Purification Techniques for Human IgG-Computer model graphics of human IgG floating in a blue and purple backgroundA yet2 client is seeking innovative technologies and methods to selectively recover specific biological molecules during a purification process at high efficiency and purity.

The primary target application is to selectively deplete the main impurities IgM, IgA, and albumin from an already quite pure polyclonal immunoglobulin G (IgG) intermediate. Novel and highly selective techniques used in purification and polishing processes are of interest. The goal of this project is to seek modern separation technologies that improve process efficiency, sustainability, and purity from current ~97% to closer to 99%.


The following criteria would be considered in scope:

  • Provide an IgG Purity: ≥99%
  • Provide a Yield: ≥95%
  • Solution should be scalable to industrial levels including eventual cost

Possible Solution Areas

  • Novel separation techniques – membrane adsorbers, resins, monoliths
  • Advances in affinity chromatography or other affinity-based separations
  • Molecular sieves, e.g., functionalized graphene
  • Non-human serum and antibodies
  • Food and agriculture industries
  • Oil and gas
  • Mining waste, decontamination, desalination

Desired Outcome of the Solution

Technologies and/or partners with solutions at a late development stage are of interest. Open to a variety of partnership avenues including Joint Development Agreements, Research Sponsorships, Licensing, Supplier etc.

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Photo Credit: Gilnature

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