Seeking: Novel Purification Techniques for Human IgG

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Novel Purification Techniques for Human IgG-Computer model graphics of human IgG floating in a blue and purple background

A yet2 client is seeking innovative technologies and methods to selectively recover specific biological molecules during a purification process at high efficiency and purity.

The primary target application is to selectively deplete the main impurities IgM, IgA, and albumin from an already quite pure polyclonal immunoglobulin G (IgG) intermediate. Novel and highly selective techniques used in purification and polishing processes are of interest. The goal of this project is to seek modern separation technologies that improve process efficiency, sustainability, and purity from current ~97% to closer to 99%.

Constraints

The following criteria would be considered in scope:

Provide an IgG Purity: ≥99%
Provide a Yield: ≥95%
Solution should be scalable to industrial levels including eventual cost

Possible Solution Areas

Novel separation techniques – membrane adsorbers, resins, monoliths
Advances in affinity chromatography or other affinity-based separations
Molecular sieves, e.g., functionalized graphene
Non-human serum and antibodies
Food and agriculture industries
Oil and gas
Mining waste, decontamination, desalination

Desired Outcome of the Solution

Technologies and/or partners with solutions at a late development stage are of interest. Open to a variety of partnership avenues including Joint Development Agreements, Research Sponsorships, Licensing, Supplier etc.